It’s easy to Scanning Exclusions for Specific Computer or User in Sophos Endpoint Security, very useful to make this only effective for the individual instead of all managed computer and users.
By default, all machine are under Base Policy. We will create another Policy to reach the goal.
Go to Policy under Endpoint Protection, Add Policy -> Feature choose Threat Protection, Type chooses User in this tutorial I choose User, the policies will follow users across their devices.
Set policy name then move the user from Available Users to Assigned Users.
Go to Settings, uncheck Use recommended settings
Scroll down to Scanning Exclusions -> Add Exclusion, you can exclusion folder or file, e.g: I exclusion folder D:\path\to\exclusion\
The added policy will appear in Threat Protection. The users can bypass from Threat scanning and only effective on folder D:\path\to\exclusion\
Hope it help.